Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo

Highlights • Resazurin is effective against Neisseria gonorrhoeae in vitro but not in vivo. • Serum albumin likely inactivates resazurin in vivo. • Resorufin pentyl ether (RPE) exhibits activity in the presence of serum albumin. • RPE reduces vaginal colonisation by N. gonorrhoeae over time. • Resaz...

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Veröffentlicht in:	International journal of antimicrobial agents 2016-10, Vol.48 (4), p.367-372
Hauptverfasser:	Schmitt, Deanna M, Connolly, Kristie L, Jerse, Ann E, Detrick, Melinda S, Horzempa, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibiotic Antimicrobial Cells, Cultured Disease Models, Animal Female Gonorrhea - drug therapy Gonorrhea - microbiology Gonorrhoea Humans Indicators and Reagents - pharmacology Infectious Disease Mice, Inbred BALB C Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - isolation & purification Oxazines - pharmacology Resazurin Resorufin Treatment Outcome Xanthenes - pharmacology
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Zusammenfassung:	Highlights • Resazurin is effective against Neisseria gonorrhoeae in vitro but not in vivo. • Serum albumin likely inactivates resazurin in vivo. • Resorufin pentyl ether (RPE) exhibits activity in the presence of serum albumin. • RPE reduces vaginal colonisation by N. gonorrhoeae over time. • Resazurin-based therapies could have potential for the treatment of gonorrhoea.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.06.009