Blood flow boosts BMP signaling to keep vessels in shape

Blood flow boosts BMP signaling to keep vessels in shape

Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress c...

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Veröffentlicht in:The Journal of cell biology 2016-09, Vol.214 (7), p.793-795
Hauptverfasser: Franco, Claudio A, Gerhardt, Holger
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood Vessels - metabolism
Blood Vessels - pathology
Bone Morphogenetic Proteins - metabolism
Mice
Models, Biological
Regional Blood Flow
Signal Transduction
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Zusammenfassung:Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201609038