Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology

Abstract Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However RSFC in young people at risk of depression has yet to be examined. 35 healthy adolescents (13–18 yrs old.) were...

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Veröffentlicht in:	Journal of psychiatric research 2016-11, Vol.82, p.40-47
Hauptverfasser:	Rzepa, Ewelina, McCabe, Ciara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biomarker Brain - diagnostic imaging Brain - physiopathology Brain Mapping Connectivity Decision Making, Computer-Assisted Depression Depressive Disorder - diagnostic imaging Depressive Disorder - physiopathology Depressive Disorder - psychology DMN Female fMRI Humans Magnetic Resonance Imaging Male Neural Pathways - diagnostic imaging Neural Pathways - physiology Oxygen - blood Pleasure - physiology Psychiatric Status Rating Scales Psychiatry Rest Resting-state Salience network Statistics as Topic Time Factors Visual Analog Scale
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Zusammenfassung:	Abstract Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However RSFC in young people at risk of depression has yet to be examined. 35 healthy adolescents (13–18 yrs old.) were recruited. 17 scoring high on the Mood and Feelings Questionnaire (MFQ > 27 (High Risk: HR), and 18 scoring low on the MFQ
ISSN:	0022-3956 1879-1379
DOI:	10.1016/j.jpsychires.2016.07.013