Acute exposure to vibration is an apoptosis‐inducing stimulus in the vocal fold epithelium

Highlights • The rate of apoptosis can be quantified in vocal fold epithelium after vibration. • Apoptosis is induced after 120 min of modal intensity phonation. • Shorter durations of vibration exposure do not result in apoptosis signaling. • TUNEL staining is positively correlated with TNF‐α prote...

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Veröffentlicht in:	Tissue & cell 2016-10, Vol.48 (5), p.407-416
Hauptverfasser:	Novaleski, Carolyn K, Kimball, Emily E, Mizuta, Masanobu, Rousseau, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Apoptosis Apoptosis - genetics Disease Models, Animal Epithelium Epithelium - metabolism Epithelium - pathology Gene Expression Regulation Humans Male Microscopy, Electron, Transmission Rabbits Signal Transduction Terminal deoxynucleotidyl transferase dUTP nick end labeling Transmission electron microscopy Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor‐alpha Vibration Vocal Cords - metabolism Vocal Cords - pathology Vocal Cords - ultrastructure Vocal fold Voice Disorders - genetics Voice Disorders - pathology
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Zusammenfassung:	Highlights • The rate of apoptosis can be quantified in vocal fold epithelium after vibration. • Apoptosis is induced after 120 min of modal intensity phonation. • Shorter durations of vibration exposure do not result in apoptosis signaling. • TUNEL staining is positively correlated with TNF‐α protein expression.
ISSN:	0040-8166 1532-3072
DOI:	10.1016/j.tice.2016.08.007