Do we need new prokinetics to reduce enteral feeding intolerance during critical illness?

Gastrointestinal feeding intolerance and critical illness-associated gastric motility dysfunction are common. Although recent guidelines recommend not interrupting gastric feeding when gastric residual volume (GRV) is lower than 500 mL or to completely abandon measurement of GRV, it may seem that th...

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Veröffentlicht in:Critical care (London, England) England), 2016-09, Vol.20 (1), p.294-294, Article 294
1. Verfasser: van Zanten, Arthur Raymond Hubert
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Sprache:eng
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Zusammenfassung:Gastrointestinal feeding intolerance and critical illness-associated gastric motility dysfunction are common. Although recent guidelines recommend not interrupting gastric feeding when gastric residual volume (GRV) is lower than 500 mL or to completely abandon measurement of GRV, it may seem that the relevance of prokinetics is reduced.In patients at risk for aspiration and in multimodal strategies to enhance feeding performance, however, use of prokinetics is still advocated. Metoclopramide and erythromycin are commonly used promotility agents, although with relevant side effects.Potential targets for new agents and early study results are addressed.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-016-1466-3