Structural basis of prokaryotic NAD-RNA decapping by NudC
In eukaryotes, the 5′,5′-triphosphate-linked 7-meth- ylguanosine (mTG) cap is essential for modulation of mRNA metabolism and protects the mRNA from degradation [1]. Removal of the cap from the 5′-terminus of the RNA is mainly carried out by decapping protein 2 (Dcp2) [2, 3] and scavenger decapping...
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Veröffentlicht in: | Cell research 2016-09, Vol.26 (9), p.1062-1066 |
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creator | Zhang, Delin Liu, Yexing Wang, Qiang Guan, Zeyuan Wang, Jing Liu, Jian Zou, Tingting Yin, Ping |
description | In eukaryotes, the 5′,5′-triphosphate-linked 7-meth- ylguanosine (mTG) cap is essential for modulation of mRNA metabolism and protects the mRNA from degradation [1]. Removal of the cap from the 5′-terminus of the RNA is mainly carried out by decapping protein 2 (Dcp2) [2, 3] and scavenger decapping enzyme (DcpS) [4]. |
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enzymology</topic><topic>Letter to the Editor</topic><topic>Life Sciences</topic><topic>Models, Molecular</topic><topic>NAD - metabolism</topic><topic>Pyrophosphatases - chemistry</topic><topic>Pyrophosphatases - metabolism</topic><topic>RNA Caps - metabolism</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Delin</creatorcontrib><creatorcontrib>Liu, Yexing</creatorcontrib><creatorcontrib>Wang, Qiang</creatorcontrib><creatorcontrib>Guan, Zeyuan</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Zou, Tingting</creatorcontrib><creatorcontrib>Yin, Ping</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Removal of the cap from the 5′-terminus of the RNA is mainly carried out by decapping protein 2 (Dcp2) [2, 3] and scavenger decapping enzyme (DcpS) [4].</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27561816</pmid><doi>10.1038/cr.2016.98</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 631/337/1645 631/535 631/80 Biomedical and Life Sciences Cell Biology Crystallography, X-Ray Escherichia coli - enzymology Letter to the Editor Life Sciences Models, Molecular NAD - metabolism Pyrophosphatases - chemistry Pyrophosphatases - metabolism RNA Caps - metabolism RNA, Messenger - metabolism |
title | Structural basis of prokaryotic NAD-RNA decapping by NudC |
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