Structural basis of prokaryotic NAD-RNA decapping by NudC

Structural basis of prokaryotic NAD-RNA decapping by NudC

In eukaryotes, the 5′,5′-triphosphate-linked 7-meth- ylguanosine （mTG） cap is essential for modulation of mRNA metabolism and protects the mRNA from degradation [1]. Removal of the cap from the 5′-terminus of the RNA is mainly carried out by decapping protein 2 （Dcp2） [2, 3] and scavenger decapping...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell research 2016-09, Vol.26 (9), p.1062-1066
Hauptverfasser: Zhang, Delin, Liu, Yexing, Wang, Qiang, Guan, Zeyuan, Wang, Jing, Liu, Jian, Zou, Tingting, Yin, Ping
Format: Artikel
Sprache:eng
Schlagworte:
631/337/1645
631/535
631/80
Biomedical and Life Sciences
Cell Biology
Crystallography, X-Ray
Escherichia coli - enzymology
Letter to the Editor
Life Sciences
Models, Molecular
NAD - metabolism
Pyrophosphatases - chemistry
Pyrophosphatases - metabolism
RNA Caps - metabolism
RNA, Messenger - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In eukaryotes, the 5′,5′-triphosphate-linked 7-meth- ylguanosine （mTG） cap is essential for modulation of mRNA metabolism and protects the mRNA from degradation [1]. Removal of the cap from the 5′-terminus of the RNA is mainly carried out by decapping protein 2 （Dcp2） [2, 3] and scavenger decapping enzyme （DcpS） [4].
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2016.98