Composition of elastin like polypeptide–collagen composite scaffold influences in vitro osteogenic activity of human adipose derived stem cells

Highlights • Improved composite mechanical properties with higher ELP and collagen content. • Promoted proliferation of hASCs on ELP-collagen scaffolds. • Increased osteogenic differentiation with higher ELP and collagen content. • A promising composite scaffold for GBR application.

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Bibliographische Detailangaben
Veröffentlicht in:	Dental materials 2016-10, Vol.32 (10), p.1270-1280
Hauptverfasser:	Gurumurthy, Bhuvaneswari, Bierdeman, Patrick C, Janorkar, Amol V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Advanced Basic Science Biocompatibility Biomedical materials Bone tissue engineering Cell Differentiation Cells, Cultured Collagen Collagens Composite scaffold Culture Dentistry Differentiation Elastic modulus Elastin Elastin-like polypeptide Guided bone regeneration Human adipose derived stem cells Humans Osteogenesis Osteogenic differentiation Peptides Scaffolds Stem Cells Tensile strength Tissue Engineering Tissue Scaffolds
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Beschreibung
Zusammenfassung:	Highlights • Improved composite mechanical properties with higher ELP and collagen content. • Promoted proliferation of hASCs on ELP-collagen scaffolds. • Increased osteogenic differentiation with higher ELP and collagen content. • A promising composite scaffold for GBR application.
ISSN:	0109-5641 1879-0097
DOI:	10.1016/j.dental.2016.07.009