KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4

Kinesin family member 23 (KIF23), a nuclear protein and a key regulator of cellular cytokinesis, has been found to be overexpressed as an oncogene in glioma. However, the prognostic and clinicopathological features of glioma with KIF23 expression was not clear yet. Here, we analyzed KIF23 expression...

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Veröffentlicht in:	Oncotarget 2016-04, Vol.7 (17), p.24646-24655
Hauptverfasser:	Sun, Lihua, Zhang, Chuanbao, Yang, Zhengxiang, Wu, Yiping, Wang, Hongjun, Bao, Zhaoshi, Jiang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Brain Neoplasms - genetics Brain Neoplasms - metabolism Cell Proliferation - physiology Female Glioma - genetics Glioma - metabolism Heterografts Humans Mice Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Prognosis Research Paper Transcription Factor 4 - genetics Transcription Factor 4 - metabolism Transfection
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Zusammenfassung:	Kinesin family member 23 (KIF23), a nuclear protein and a key regulator of cellular cytokinesis, has been found to be overexpressed as an oncogene in glioma. However, the prognostic and clinicopathological features of glioma with KIF23 expression was not clear yet. Here, we analyzed KIF23 expression pattern by using whole genome mRNA expression microarray data from Chinese Glioma Genome Atlas (CGGA) database (http://www.cgga.org.cn), and found that KIF23 overexpression was significantly associated with high grade glioma as well as the higher mortality in survival analysis (log-rank test, p
ISSN:	1949-2553 1949-2553
DOI:	10.18632/oncotarget.8261