Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis

Over-expression of TROP2 (the trophoblast cell surface antigen 2) was reported to predict poor prognosis in various solid tumors in number of studies. However, the results remained not comprehensive. Therefore, we here carried out this meta-analysis of relevant studies published on this topic to qua...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.33658-33658, Article 33658
Hauptverfasser:	Zeng, Ping, Chen, Min-Bin, Zhou, Li-Na, Tang, Min, Liu, Chao-Ying, Lu, Pei-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1857 692/53/2422 Cell surface Humanities and Social Sciences Medical prognosis Meta-analysis multidisciplinary Overexpression Prognosis Science Solid tumors Survival Tumors
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Zusammenfassung:	Over-expression of TROP2 (the trophoblast cell surface antigen 2) was reported to predict poor prognosis in various solid tumors in number of studies. However, the results remained not comprehensive. Therefore, we here carried out this meta-analysis of relevant studies published on this topic to quantitatively evaluate the clinicopathological significance of TROP2 in solid tumors. Relevant articles were identified through searching the PubMed, Web of Science and Embase database. The primary outcomes were overall survival (OS) and disease-free survival (DFS). In this meta-analysis, 16 studies involving 2,569 participants were included and we drew the conclusion that TROP2 overexpression was significantly associated with poor OS (pooled HR = 1.896, 95% CI = 1.599–2.247, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep33658