Food Fight: Role of Itaconate and Other Metabolites in Anti-Microbial Defense
Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and anti-microbial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle tha...
Gespeichert in:
| Veröffentlicht in: | Cell metabolism 2016-09, Vol.24 (3), p.379-387 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and anti-microbial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics. |
|---|---|
| ISSN: | 1550-4131 1932-7420 |
| DOI: | 10.1016/j.cmet.2016.08.013 |