Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease

Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease

Objective The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD...

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Veröffentlicht in:Annals of clinical and translational neurology 2016-09, Vol.3 (9), p.668-677
Hauptverfasser: Bonham, Luke W., Geier, Ethan G., Fan, Chun C., Leong, Josiah K., Besser, Lilah, Kukull, Walter A., Kornak, John, Andreassen, Ole A., Schellenberg, Gerard D., Rosen, Howard J., Dillon, William P., Hess, Christopher P., Miller, Bruce L., Dale, Anders M., Desikan, Rahul S., Yokoyama, Jennifer S.
Format: Artikel
Sprache:eng
Schlagworte:
Age groups
Aging
Alzheimer's disease
Consortia
Dementia
Genotype & phenotype
Grants
Health risk assessment
Studies
Survival analysis
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Zusammenfassung:Objective The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD. Methods Using data from 5381 cognitively normal older individuals and Cox proportional hazards models, we longitudinally tested the effects of APOE genotype on progression from normal cognition to mild cognitive impairment (MCI) or AD in four age strata (
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.333