Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis

BackgroundParkinson’s disease (PD) is 1.5 times more frequent in men than women. Whether age modifies this ratio is unclear. We examined whether male-to-female (M–F) ratios change with age through a French nationwide prevalence/incidence study (2010) and a meta-analysis of incidence studies.MethodsW...

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Veröffentlicht in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2016-09, Vol.87 (9), p.952-957
Hauptverfasser: Moisan, Frédéric, Kab, Sofiane, Mohamed, Fatima, Canonico, Marianne, Le Guern, Morgane, Quintin, Cécile, Carcaillon, Laure, Nicolau, Javier, Duport, Nicolas, Singh-Manoux, Archana, Boussac-Zarebska, Marjorie, Elbaz, Alexis
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Sprache:eng
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Zusammenfassung:BackgroundParkinson’s disease (PD) is 1.5 times more frequent in men than women. Whether age modifies this ratio is unclear. We examined whether male-to-female (M–F) ratios change with age through a French nationwide prevalence/incidence study (2010) and a meta-analysis of incidence studies.MethodsWe used French national drug claims databases to identify PD cases using a validated algorithm. We computed M–F prevalence/incidence ratios overall and by age using Poisson regression. Ratios were regressed on age to estimate their annual change. We identified all PD incidence studies with age/sex-specific data, and performed a meta-analysis of M–F ratios.ResultsOn the basis of 149 672 prevalent (50% women) and 25 438 incident (49% women) cases, age-standardised rates were higher in men (prevalence=2.865/1000; incidence=0.490/1000 person-years) than women (prevalence=1.934/1000; incidence=0.328/1000 person-years). The overall M–F ratio was 1.48 for prevalence and 1.49 for incidence. Prevalence and incidence M–F ratios increased by 0.05 and 0.14, respectively, per 10 years of age. Incidence was similar in men and women under 50 years (M–F ratio 0.20), and over 1.6 (p
ISSN:0022-3050
1468-330X
1468-330X
DOI:10.1136/jnnp-2015-312283