Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4+ T cells but no increase in avidity for Ag85A

Highlights • BCG-Ad5-85A protection was associated with higher CD4+ Ag85A-specific cell frequency. • BCG-Ad5-85A protection was not associated with increased CD4+ Ag85A-specific avidity. • BCG-Ad5-85A protection was not associated with epitope spreading.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-08, Vol.34 (38), p.4520-4525
Hauptverfasser:	Metcalfe, Hannah J, Steinbach, Sabine, Jones, Gareth J, Connelley, Tim, Morrison, W. Ivan, Vordermeier, Martin, Villarreal-Ramos, Bernardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - immunology Adenoviridae Adenovirus Allergy and Immunology Animals Antigens Antigens, Bacterial - immunology BCG Vaccine - immunology Bovine tuberculosis Cattle CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology cows epitopes Epitopes, T-Lymphocyte - immunology Experiments Female Funding Human mastadenovirus C humans Immune response Immunological protection Infections Leukocytes, Mononuclear - immunology Lymphocytes Methods Mycobacterium bovis Proteins T cell receptors Tuberculosis Tuberculosis - prevention & control Vaccination Vaccines Vectors (Biology)
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Beschreibung
Zusammenfassung:	Highlights • BCG-Ad5-85A protection was associated with higher CD4+ Ag85A-specific cell frequency. • BCG-Ad5-85A protection was not associated with increased CD4+ Ag85A-specific avidity. • BCG-Ad5-85A protection was not associated with epitope spreading.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.07.055