Malignant melanoma showing smooth muscle differentiation

A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and...

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Veröffentlicht in:	Journal of clinical pathology 1996-11, Vol.49 (11), p.950-951
Hauptverfasser:	Banerjee, S S, Bishop, P W, Nicholson, C M, Eyden, B P
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Biological and medical sciences Dermatology Desmin - metabolism Female Humans Immunohistochemistry Lymphatic Metastasis Medical sciences Melanoma - metabolism Melanoma - pathology Melanoma - secondary Middle Aged Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.
ISSN:	0021-9746 1472-4146
DOI:	10.1136/jcp.49.11.950