Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients

Oral cavity squamous cell carcinoma may be more aggressive at presentation and recurrence in young patients compared with older patients. Dysregulation of microRNAs (miRNAs or miRs) has been associated with the development and prognosis of oral cavity cancer. The present study investigated miRNA exp...

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Veröffentlicht in:	Oncology letters 2016-09, Vol.12 (3), p.1729-1736
Hauptverfasser:	Hilly, Ohad, Pillar, Nir, Stern, Sagit, Strenov, Yulia, Bachar, Gideon, Shomron, Noam, Shpitzer, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age factors in disease Care and treatment Development and progression Gene expression Genetic aspects Head & neck cancer Health aspects Metastasis MicroRNA MicroRNAs Mortality Observations oral cavity cancer Patients Properties Self control Squamous cell carcinoma Studies Tongue cancer Tumors young patients
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Zusammenfassung:	Oral cavity squamous cell carcinoma may be more aggressive at presentation and recurrence in young patients compared with older patients. Dysregulation of microRNAs (miRNAs or miRs) has been associated with the development and prognosis of oral cavity cancer. The present study investigated miRNA expression in carcinoma of the oral tongue in young patients. miRNA expression profiles were evaluated in formalin-fixed, paraffin-embedded samples of tumor and normal mucosa from 12 patients aged
ISSN:	1792-1074 1792-1082
DOI:	10.3892/ol.2016.4892