The heterogeneity of store-operated calcium entry in melanoma

Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry （SOCE）, the main pathway for calcium entry in non-excitable cells. Changes in the expression and fu...

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Veröffentlicht in:	Science China. Life sciences 2016-08, Vol.59 (8), p.764-769
Hauptverfasser:	Hooper, Robert, Zaidi, M. Raza, Soboloff, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Calcium - metabolism Calcium Signaling Cell Membrane - metabolism Endoplasmic Reticulum - metabolism Humans Life Sciences Melanoma - metabolism Models, Biological ORAI1 Protein - metabolism Review Stromal Interaction Molecule 1 - metabolism
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Zusammenfassung:	Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry （SOCE）, the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.
ISSN:	1674-7305 1869-1889
DOI:	10.1007/s11427-016-5087-5