Morphofunctional Abnormalities of Mitral Annulus and Arrhythmic Mitral Valve Prolapse

Arrhythmic mitral valve prolapse (MVP) is characterized by myxomatous leaflets and left ventricular (LV) fibrosis of papillary muscles and inferobasal wall. We searched for morphofunctional abnormalities of the mitral valve that could explain a regional mechanical myocardial stretch. Thirty-six (27...

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Veröffentlicht in:	Circulation. Cardiovascular imaging 2016-08, Vol.9 (8), p.e005030-e005030
Hauptverfasser:	Perazzolo Marra, Martina, Basso, Cristina, De Lazzari, Manuel, Rizzo, Stefania, Cipriani, Alberto, Giorgi, Benedetta, Lacognata, Carmelo, Rigato, Ilaria, Migliore, Federico, Pilichou, Kalliopi, Cacciavillani, Luisa, Bertaglia, Emanuele, Frigo, Anna Chiara, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Iliceto, Sabino
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arrhythmias, Cardiac - complications Arrhythmias, Cardiac - diagnostic imaging Arrhythmias, Cardiac - mortality Arrhythmias, Cardiac - physiopathology Biopsy Contrast Media - administration & dosage Death, Sudden, Cardiac - etiology Echocardiography Electrocardiography, Ambulatory Female Fibrosis Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - mortality Hypertrophy, Left Ventricular - physiopathology Linear Models Magnetic Resonance Imaging Male Middle Aged Mitral Valve - diagnostic imaging Mitral Valve - physiopathology Mitral Valve Prolapse - diagnostic imaging Mitral Valve Prolapse - etiology Mitral Valve Prolapse - mortality Mitral Valve Prolapse - physiopathology Original Papillary Muscles - diagnostic imaging Papillary Muscles - physiopathology Prognosis Risk Factors Ventricular Function, Left Young Adult
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Zusammenfassung:	Arrhythmic mitral valve prolapse (MVP) is characterized by myxomatous leaflets and left ventricular (LV) fibrosis of papillary muscles and inferobasal wall. We searched for morphofunctional abnormalities of the mitral valve that could explain a regional mechanical myocardial stretch. Thirty-six (27 female patients; median age: 44 years) arrhythmic MVP patients with LV late gadolinium enhancement on cardiac magnetic resonance and no or trivial mitral regurgitation, and 16 (6 female patients; median age: 40 years) MVP patients without LV late gadolinium enhancement were investigated by morphofunctional cardiac magnetic resonance. Mitral annulus disjunction (median: 4.8 versus 1.8 mm; P
ISSN:	1941-9651 1942-0080
DOI:	10.1161/CIRCIMAGING.116.005030