Association between choroidal thickness and anterior chamber segment in eyes with narrow or open-angle

AIM: To investigate the relationship between choroidal thickness and anterior chamber segment in subjects with eyes with narrow or open-angle.METHODS: The subfoveal choroidal thickness was measured with enhanced depth-imaging optical coherence tomography and anterior chamber parameters were measured with ultrasound biomicroscopy in one eye of 23 subjects with open-angle eyes and 38 subjects with narrow-angle eyes. The mean age was 59.52 ±7.04 y for narrow-angle subjects and 60.76 ±7.23 y for open-angle subjects(P =0.514). Multivariate linear regression analysis was performed to assess the association between choroidal thickness and narrow-angle parameters.RESULTS: There were no differences in subfoveal choroidal thickness between open- and narrow-angle subjects(P =0.231). Anterior chamber parameters,including central anterior chamber depth, trabecular iris angle, iris thickness 500 μm from the scleral spur(IT500),and ciliary body thickness at 1 mm and 2 mm from the scleral spur(CBT1, CBT2) showed significant differences between the two groups(P <0.05). Subfoveal choroidal thickness showed negative correlation(β =-0.496, P =0.016) only with anterior chamber depth in the open-angle group and with age(β =-0.442, P =0.003) and IT500(β =-0.399, P =0.008) in the narrow-angle group.However, subfoveal choroidal thickness was not correlated with trabecular iris angle, anterior chamber depth, ciliary body thickness, or central corneal thickness in the narrow-angle group.CONCLUSION: Choroidal thickness does not differ in the two groups and has not correlated with anterior chamber parameters in narrow-angle subjects,suggesting a lack of relationship between choroidal thickness and primary angle-closure glaucoma.