A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). The controversy may be attributable to presence of potential confounding factors such as MGMT methylation status or patients' treatment. This study aimed to evaluate the impac...

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Veröffentlicht in:	Acta neuropathologica communications 2016-08, Vol.4 (1), p.79, Article 79
Hauptverfasser:	Arita, Hideyuki, Yamasaki, Kai, Matsushita, Yuko, Nakamura, Taishi, Shimokawa, Asanao, Takami, Hirokazu, Tanaka, Shota, Mukasa, Akitake, Shirahata, Mitsuaki, Shimizu, Saki, Suzuki, Kaori, Saito, Kuniaki, Kobayashi, Keiichi, Higuchi, Fumi, Uzuka, Takeo, Otani, Ryohei, Tamura, Kaoru, Sumita, Kazutaka, Ohno, Makoto, Miyakita, Yasuji, Kagawa, Naoki, Hashimoto, Naoya, Hatae, Ryusuke, Yoshimoto, Koji, Shinojima, Naoki, Nakamura, Hideo, Kanemura, Yonehiro, Okita, Yoshiko, Kinoshita, Manabu, Ishibashi, Kenichi, Shofuda, Tomoko, Kodama, Yoshinori, Mori, Kanji, Tomogane, Yusuke, Fukai, Junya, Fujita, Koji, Terakawa, Yuzo, Tsuyuguchi, Naohiro, Moriuchi, Shusuke, Nonaka, Masahiro, Suzuki, Hiroyoshi, Shibuya, Makoto, Maehara, Taketoshi, Saito, Nobuhito, Nagane, Motoo, Kawahara, Nobutaka, Ueki, Keisuke, Yoshimine, Toshiki, Miyaoka, Etsuo, Nishikawa, Ryo, Komori, Takashi, Narita, Yoshitaka, Ichimura, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Antineoplastic Agents, Alkylating - therapeutic use Biomarkers, Tumor - genetics Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Cohort Studies Combined Modality Therapy Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use DNA Methylation DNA Modification Methylases - genetics DNA Repair Enzymes - genetics Female Genetic aspects Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - radiotherapy Glioblastoma - surgery Gliomas Humans Isocitrate Dehydrogenase - genetics Japan Male Medical research Medicine, Experimental Methylation Middle Aged Mutation Promoter Regions, Genetic Survival Analysis Telomerase - genetics Temozolomide Tumor Suppressor Proteins - genetics
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Zusammenfassung:	The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). The controversy may be attributable to presence of potential confounding factors such as MGMT methylation status or patients' treatment. This study aimed to evaluate the impact of TERT status on patient outcome in association with various factors in a large series of adult diffuse gliomas. We analyzed a total of 951 adult diffuse gliomas from two cohorts (Cohort 1, n = 758; Cohort 2, n = 193) for IDH1/2, 1p/19q, and TERT promoter status. The combined IDH/TERT classification divided Cohort 1 into four molecular groups with distinct outcomes. The overall survival (OS) was the shortest in IDH wild-type/TERT mutated groups, which mostly consisted of GBMs (P
ISSN:	2051-5960 2051-5960
DOI:	10.1186/s40478-016-0351-2