The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression

Highlights • Cortisol response to ACTH is affected by sex and irritable bowel syndrome (IBS). • Response is increased in men but blunted in women with IBS compared to controls. • Glucocorticoid receptor α (GRα) mRNA is reduced in IBS and negatively correlates with ACTH response. • Low expression of...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-07, Vol.69, p.67-76
Hauptverfasser:	Videlock, Elizabeth J, Shih, Wendy, Adeyemo, Mopelola, Mahurkar, Swapna, Presson, Angela P, Polytarchou, Christos, Alberto, Melissa, Iliopoulos, Dimitrios, Mayer, Emeran A, Chang, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal cortex hormones Adrenocorticotropic Hormone - metabolism Adult Case-Control Studies Corticotropin-Releasing Hormone - metabolism Endocrinology & Metabolism Female Gene Expression Regulation - genetics Glucocorticoids - pharmacology Glucocorticoids receptors Humans Hydrocortisone - metabolism Hydrocortisone - physiology Hypothalamic pituitary-regulating hormones Hypothalamo-Hypophyseal System - metabolism Irritable bowel syndrome Irritable Bowel Syndrome - complications Irritable Bowel Syndrome - physiopathology Irritable Bowel Syndrome - psychology Leukocytes, Mononuclear - metabolism Male Middle Aged Pituitary-Adrenal System - metabolism Psychiatry Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Sex differences Sex Factors
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Zusammenfassung:	Highlights • Cortisol response to ACTH is affected by sex and irritable bowel syndrome (IBS). • Response is increased in men but blunted in women with IBS compared to controls. • Glucocorticoid receptor α (GRα) mRNA is reduced in IBS and negatively correlates with ACTH response. • Low expression of GRα is associated with increased symptom severity in IBS.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.03.016