Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression
Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes.
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2016-09, Vol.380 (1), p.153-162 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 162 |
|---|---|
| container_issue | 1 |
| container_start_page | 153 |
| container_title | Cancer letters |
| container_volume | 380 |
| creator | Huang, Chiung-Kuei Aihara, Arihiro Iwagami, Yoshifumi Yu, Tunan Carlson, Rolf Koga, Hironori Kim, Miran Zou, Jing Casulli, Sarah Wands, Jack R |
| description | Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes. |
| doi_str_mv | 10.1016/j.canlet.2016.05.038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4973469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383516303810</els_id><sourcerecordid>1807880502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4998-ed06d86b71f011a52e0b0adbd0674548576d028004844ce1e083feb33b642e83</originalsourceid><addsrcrecordid>eNqFkstu1DAUhi1ERYe2b4BQlmwSjmMncTZIqCoXqRILurcc-yTjIbGDnRnoa_EgPBOOZiiXTVeW7f_85_IdQl5QKCjQ-vWu0MqNuBRluhVQFcDEE7KhoinzphXwlGyAAc-ZYNU5eR7jDgAq3lTPyHnZsJq3Dd8Qc_N9Dhij9S7zfbYE5WLvw2TdkA3Bf1u2Wa_04kP28wfN5uAnv2DM9NaPyg3WaxW0dX5SmcEDjn6e0C2ZcmbVDifnS3LWqzHi1em8IHfvbu6uP-S3n95_vH57m2vetiJHA7URddfQHihVVYnQgTJdem54xUXV1AZKAcAF5xopgmA9dox1NS9RsAvy5mg777sJjU6VBDXKOdhJhXvplZX__ji7lYM_yDQKxus2Gbw6GQT_dY9xkZONGsfUKvp9lFRAIwRUUCYpP0p18DEG7B_SUJArH7mTRz5y5SOhkolPCnv5d4kPQb-B_OkB05wOFoOM2qLTaGxAvUjj7WMZ_jfQo3VWq_EL3mPc-X1wiYGkMpYS5Od1R9YVoTVL4RTYL66nu98</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1807880502</pqid></control><display><type>article</type><title>Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Huang, Chiung-Kuei ; Aihara, Arihiro ; Iwagami, Yoshifumi ; Yu, Tunan ; Carlson, Rolf ; Koga, Hironori ; Kim, Miran ; Zou, Jing ; Casulli, Sarah ; Wands, Jack R</creator><creatorcontrib>Huang, Chiung-Kuei ; Aihara, Arihiro ; Iwagami, Yoshifumi ; Yu, Tunan ; Carlson, Rolf ; Koga, Hironori ; Kim, Miran ; Zou, Jing ; Casulli, Sarah ; Wands, Jack R</creatorcontrib><description>Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2016.05.038</identifier><identifier>PMID: 27364974</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Bile Duct Neoplasms - genetics ; Bile Duct Neoplasms - metabolism ; Bile Duct Neoplasms - pathology ; Bile duct tumor ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cholangiocarcinoma - genetics ; Cholangiocarcinoma - metabolism ; Cholangiocarcinoma - pathology ; Cyclin D1 - genetics ; Cyclin D1 - metabolism ; Cyclin-Dependent Kinase 6 - genetics ; Cyclin-Dependent Kinase 6 - metabolism ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Hematology, Oncology and Palliative Medicine ; Humans ; Liver fibrosis ; Male ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA-34a ; Neoplasms, Experimental - genetics ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - pathology ; Proto-Oncogene Proteins c-met - genetics ; Proto-Oncogene Proteins c-met - metabolism ; Rats ; Rats, Inbred F344 ; RNA Interference ; Signal Transduction ; TGFβ1 inhibitor ; Transfection ; Transforming Growth Factor beta1 - antagonists & inhibitors ; Transforming Growth Factor beta1 - genetics ; Transforming Growth Factor beta1 - metabolism ; Up-Regulation</subject><ispartof>Cancer letters, 2016-09, Vol.380 (1), p.153-162</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4998-ed06d86b71f011a52e0b0adbd0674548576d028004844ce1e083feb33b642e83</citedby><cites>FETCH-LOGICAL-c4998-ed06d86b71f011a52e0b0adbd0674548576d028004844ce1e083feb33b642e83</cites><orcidid>0000-0001-8029-5686 ; 0000-0002-6965-8754</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2016.05.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27364974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chiung-Kuei</creatorcontrib><creatorcontrib>Aihara, Arihiro</creatorcontrib><creatorcontrib>Iwagami, Yoshifumi</creatorcontrib><creatorcontrib>Yu, Tunan</creatorcontrib><creatorcontrib>Carlson, Rolf</creatorcontrib><creatorcontrib>Koga, Hironori</creatorcontrib><creatorcontrib>Kim, Miran</creatorcontrib><creatorcontrib>Zou, Jing</creatorcontrib><creatorcontrib>Casulli, Sarah</creatorcontrib><creatorcontrib>Wands, Jack R</creatorcontrib><title>Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes.</description><subject>Animals</subject><subject>Bile Duct Neoplasms - genetics</subject><subject>Bile Duct Neoplasms - metabolism</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile duct tumor</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cholangiocarcinoma - genetics</subject><subject>Cholangiocarcinoma - metabolism</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cyclin D1 - genetics</subject><subject>Cyclin D1 - metabolism</subject><subject>Cyclin-Dependent Kinase 6 - genetics</subject><subject>Cyclin-Dependent Kinase 6 - metabolism</subject><subject>Disease Progression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Liver fibrosis</subject><subject>Male</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA-34a</subject><subject>Neoplasms, Experimental - genetics</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Proto-Oncogene Proteins c-met - genetics</subject><subject>Proto-Oncogene Proteins c-met - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>RNA Interference</subject><subject>Signal Transduction</subject><subject>TGFβ1 inhibitor</subject><subject>Transfection</subject><subject>Transforming Growth Factor beta1 - antagonists & inhibitors</subject><subject>Transforming Growth Factor beta1 - genetics</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>Up-Regulation</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAUhi1ERYe2b4BQlmwSjmMncTZIqCoXqRILurcc-yTjIbGDnRnoa_EgPBOOZiiXTVeW7f_85_IdQl5QKCjQ-vWu0MqNuBRluhVQFcDEE7KhoinzphXwlGyAAc-ZYNU5eR7jDgAq3lTPyHnZsJq3Dd8Qc_N9Dhij9S7zfbYE5WLvw2TdkA3Bf1u2Wa_04kP28wfN5uAnv2DM9NaPyg3WaxW0dX5SmcEDjn6e0C2ZcmbVDifnS3LWqzHi1em8IHfvbu6uP-S3n95_vH57m2vetiJHA7URddfQHihVVYnQgTJdem54xUXV1AZKAcAF5xopgmA9dox1NS9RsAvy5mg777sJjU6VBDXKOdhJhXvplZX__ji7lYM_yDQKxus2Gbw6GQT_dY9xkZONGsfUKvp9lFRAIwRUUCYpP0p18DEG7B_SUJArH7mTRz5y5SOhkolPCnv5d4kPQb-B_OkB05wOFoOM2qLTaGxAvUjj7WMZ_jfQo3VWq_EL3mPc-X1wiYGkMpYS5Od1R9YVoTVL4RTYL66nu98</recordid><startdate>20160928</startdate><enddate>20160928</enddate><creator>Huang, Chiung-Kuei</creator><creator>Aihara, Arihiro</creator><creator>Iwagami, Yoshifumi</creator><creator>Yu, Tunan</creator><creator>Carlson, Rolf</creator><creator>Koga, Hironori</creator><creator>Kim, Miran</creator><creator>Zou, Jing</creator><creator>Casulli, Sarah</creator><creator>Wands, Jack R</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8029-5686</orcidid><orcidid>https://orcid.org/0000-0002-6965-8754</orcidid></search><sort><creationdate>20160928</creationdate><title>Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression</title><author>Huang, Chiung-Kuei ; Aihara, Arihiro ; Iwagami, Yoshifumi ; Yu, Tunan ; Carlson, Rolf ; Koga, Hironori ; Kim, Miran ; Zou, Jing ; Casulli, Sarah ; Wands, Jack R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4998-ed06d86b71f011a52e0b0adbd0674548576d028004844ce1e083feb33b642e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bile Duct Neoplasms - genetics</topic><topic>Bile Duct Neoplasms - metabolism</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile duct tumor</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cholangiocarcinoma - genetics</topic><topic>Cholangiocarcinoma - metabolism</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cyclin D1 - genetics</topic><topic>Cyclin D1 - metabolism</topic><topic>Cyclin-Dependent Kinase 6 - genetics</topic><topic>Cyclin-Dependent Kinase 6 - metabolism</topic><topic>Disease Progression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Liver fibrosis</topic><topic>Male</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA-34a</topic><topic>Neoplasms, Experimental - genetics</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Proto-Oncogene Proteins c-met - genetics</topic><topic>Proto-Oncogene Proteins c-met - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>RNA Interference</topic><topic>Signal Transduction</topic><topic>TGFβ1 inhibitor</topic><topic>Transfection</topic><topic>Transforming Growth Factor beta1 - antagonists & inhibitors</topic><topic>Transforming Growth Factor beta1 - genetics</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chiung-Kuei</creatorcontrib><creatorcontrib>Aihara, Arihiro</creatorcontrib><creatorcontrib>Iwagami, Yoshifumi</creatorcontrib><creatorcontrib>Yu, Tunan</creatorcontrib><creatorcontrib>Carlson, Rolf</creatorcontrib><creatorcontrib>Koga, Hironori</creatorcontrib><creatorcontrib>Kim, Miran</creatorcontrib><creatorcontrib>Zou, Jing</creatorcontrib><creatorcontrib>Casulli, Sarah</creatorcontrib><creatorcontrib>Wands, Jack R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chiung-Kuei</au><au>Aihara, Arihiro</au><au>Iwagami, Yoshifumi</au><au>Yu, Tunan</au><au>Carlson, Rolf</au><au>Koga, Hironori</au><au>Kim, Miran</au><au>Zou, Jing</au><au>Casulli, Sarah</au><au>Wands, Jack R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2016-09-28</date><risdate>2016</risdate><volume>380</volume><issue>1</issue><spage>153</spage><epage>162</epage><pages>153-162</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>27364974</pmid><doi>10.1016/j.canlet.2016.05.038</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8029-5686</orcidid><orcidid>https://orcid.org/0000-0002-6965-8754</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2016-09, Vol.380 (1), p.153-162 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4973469 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Bile Duct Neoplasms - genetics Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Bile duct tumor Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cholangiocarcinoma - genetics Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase 6 - genetics Cyclin-Dependent Kinase 6 - metabolism Disease Progression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Liver fibrosis Male MicroRNAs - genetics MicroRNAs - metabolism miRNA-34a Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Rats Rats, Inbred F344 RNA Interference Signal Transduction TGFβ1 inhibitor Transfection Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Up-Regulation |
| title | Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A18%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20transforming%20growth%20factor%20%CE%B21%20promotes%20cholangiocarcinoma%20development%20and%20progression&rft.jtitle=Cancer%20letters&rft.au=Huang,%20Chiung-Kuei&rft.date=2016-09-28&rft.volume=380&rft.issue=1&rft.spage=153&rft.epage=162&rft.pages=153-162&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2016.05.038&rft_dat=%3Cproquest_pubme%3E1807880502%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1807880502&rft_id=info:pmid/27364974&rft_els_id=S0304383516303810&rfr_iscdi=true |