Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression

Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-09, Vol.380 (1), p.153-162
Hauptverfasser:	Huang, Chiung-Kuei, Aihara, Arihiro, Iwagami, Yoshifumi, Yu, Tunan, Carlson, Rolf, Koga, Hironori, Kim, Miran, Zou, Jing, Casulli, Sarah, Wands, Jack R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Duct Neoplasms - genetics Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Bile duct tumor Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cholangiocarcinoma - genetics Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase 6 - genetics Cyclin-Dependent Kinase 6 - metabolism Disease Progression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Liver fibrosis Male MicroRNAs - genetics MicroRNAs - metabolism miRNA-34a Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Rats Rats, Inbred F344 RNA Interference Signal Transduction TGFβ1 inhibitor Transfection Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights • TGFβ1 promotes malignant transformation of cholangiocarcinoma (CCA). • Overexpression of TGFβ1 accelerates CCA progression. • TGFβ1 alters CCA growth through miR-34a targeted genes.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.05.038