Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types

Dear Editor, Cancer is prevalent worldwide. Currently, most routinely used non-invasive serological cancer biomarkers, including carcino-embryonic antigen （CEA）, prostate-specific antigen （PSA）, α-fetoprotein （AFP）, CA125, CA15-3, and CA19-9, suffer from low specificity and/ or low sensitivity [1]....

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Veröffentlicht in:	Cell research 2016-08, Vol.26 (8), p.963-966
Hauptverfasser:	Ren, Shifang, Zhang, Zejian, Xu, Congjian, Guo, Lin, Lu, Renquan, Sun, Yihong, Guo, Jianming, Qin, Ruihuan, Qin, Wenjun, Gu, Jianxin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1857 631/67/2322 631/80/458/1524 Biomarkers, Tumor - blood Biomarkers, Tumor - chemistry Biomedical and Life Sciences Cell Biology Cohort Studies Early Detection of Cancer - methods Female Galactose - metabolism Glycosylation Humans IgG Immunoglobulin G - blood Immunoglobulin G - chemistry Immunoglobulin G - immunology Letter to the Editor Life Sciences Male Neoplasms - blood Neoplasms - diagnosis Neoplasms - immunology 特异性抗原生物标志物癌症筛查类型糖分肿瘤标志物
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Zusammenfassung:	Dear Editor, Cancer is prevalent worldwide. Currently, most routinely used non-invasive serological cancer biomarkers, including carcino-embryonic antigen （CEA）, prostate-specific antigen （PSA）, α-fetoprotein （AFP）, CA125, CA15-3, and CA19-9, suffer from low specificity and/ or low sensitivity [1]. Improvements in timely and effective diagnosis of cancer are urgently needed.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2016.83