Specific KRAS amino acid substitutions and EGFR mutations predict site-specific recurrence and metastasis following non-small-cell lung cancer surgery

Background: We aimed to evaluate whether EGFR mutations ( mEGFR ) and KRAS amino acid substitutions can predict first site of recurrence or metastasis after non-small-cell lung cancer (NSCLC) surgery. Methods: Data were reviewed from 481 patients who underwent thoracic surgery for NSCLC between 2007...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2016-07, Vol.115 (3), p.346-353
Hauptverfasser:	Renaud, Stéphane, Seitlinger, Joseph, Falcoz, Pierre-Emmanuel, Schaeffer, Mickaël, Voegeli, Anne-Claire, Legrain, Michèle, Beau-Faller, Michèle, Massard, Gilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/755 692/699/67/1612/1350 692/699/67/322 692/700/565/545 Aged Amino Acid Substitution Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Drug Resistance Epidemiology Female Genes, ras Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - surgery Male Middle Aged Molecular Diagnostics Molecular Medicine Mutation Neoplasm Metastasis Neoplasm Recurrence, Local Oncology Receptor, Epidermal Growth Factor - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: We aimed to evaluate whether EGFR mutations ( mEGFR ) and KRAS amino acid substitutions can predict first site of recurrence or metastasis after non-small-cell lung cancer (NSCLC) surgery. Methods: Data were reviewed from 481 patients who underwent thoracic surgery for NSCLC between 2007 and 2012. Results: Patients with KRAS G12C developed significantly more bone metastases compared with the remainder of the cohort (59% vs 16%, P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2016.182