Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels

Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function. Objective...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2016-08, Vol.101 (8), p.3096-3104
Hauptverfasser:	Cunningham, Glenn R, Stephens-Shields, Alisa J, Rosen, Raymond C, Wang, Christina, Bhasin, Shalender, Matsumoto, Alvin M, Parsons, J. Kellogg, Gill, Thomas M, Molitch, Mark E, Farrar, John T, Cella, David, Barrett-Connor, Elizabeth, Cauley, Jane A, Cifelli, Denise, Crandall, Jill P, Ensrud, Kristine E, Gallagher, Laura, Zeldow, Bret, Lewis, Cora E, Pahor, Marco, Swerdloff, Ronald S, Hou, Xiaoling, Anton, Stephen, Basaria, Shehzad, Diem, Susan J, Tabatabaie, Vafa, Ellenberg, Susan S, Snyder, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Erectile Dysfunction - drug therapy Hormone Replacement Therapy Humans Libido - drug effects Male Original Placebos Sexual Behavior - drug effects Sexual Dysfunction, Physiological - blood Sexual Dysfunction, Physiological - drug therapy Sexual Dysfunction, Physiological - physiopathology Surveys and Questionnaires Testosterone - blood Testosterone - therapeutic use Treatment Outcome
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Zusammenfassung:	Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function. Objective: To assess the responsiveness of specific sexual activities to T treatment; to relate hormone changes to changes in sexual function; and to determine predictive baseline characteristics and T threshold for sexual outcomes. Design: A placebo-controlled trial. Setting: Twelve academic medical centers in the United States. Participants: A total of 470 men ≥65 years of age with low libido, average T
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2016-1645