A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17

Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes,...

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Veröffentlicht in:	The Journal of cell biology 2016-08, Vol.214 (3), p.241-243
1. Verfasser:	Juhász, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cellular biology Cytoplasmic Vesicles - metabolism Drosophila melanogaster - metabolism Endoplasmic Reticulum - metabolism Endosomes - metabolism Humans Lysosomes - metabolism Mitochondria Mitochondria - metabolism Mitochondrial Proteins - metabolism Models, Biological Multiprotein Complexes - metabolism Parkinson Disease - metabolism Parkinson Disease - pathology Phagosomes - metabolism Proteins Qa-SNARE Proteins - metabolism SNARE Proteins - metabolism
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Zusammenfassung:	Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation.
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.201607024