DNA Damage and Aging Around the Clock

DNA Damage and Aging Around the Clock

The hematopoietic system undergoes many changes during aging, but the causes and molecular mechanisms behind these changes are not well understood. Wang et al. have recently implicated a circadian rhythm gene, Per2 , as playing a role in the DNA damage response and in the expression of lymphoid gene...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in molecular medicine 2016-08, Vol.22 (8), p.635-637
Hauptverfasser: Gutierrez-Martinez, Paula, Rossi, Derrick J, Beerman, Isabel
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Circadian Rhythm
DNA Damage
Gene Expression Regulation
Hematopoiesis
Humans
Pathology
Period Circadian Proteins - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The hematopoietic system undergoes many changes during aging, but the causes and molecular mechanisms behind these changes are not well understood. Wang et al. have recently implicated a circadian rhythm gene, Per2 , as playing a role in the DNA damage response and in the expression of lymphoid genes in aged hematopoietic stem cells.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2016.06.006