Osteoporosis: The Result of an ‘Aged’ Bone Microenvironment

Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics, cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms and players underlying the pathology of osteoporosis, supporting a model of age-related dysregulation and crosstalk in the bo...

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Veröffentlicht in:	Trends in molecular medicine 2016-08, Vol.22 (8), p.641-644
Hauptverfasser:	Yu, Bo, Wang, Cun-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Aging Animals Bone and Bones - immunology Bone and Bones - metabolism Bone and Bones - pathology Drug Delivery Systems Drug Discovery epigenetics Female Humans Male osteoimmunology osteoporosis Osteoporosis - etiology Osteoporosis - immunology Osteoporosis - metabolism Osteoporosis - pathology Pathology Wnt signaling Wnt Signaling Pathway - drug effects
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Beschreibung
Zusammenfassung:	Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics, cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms and players underlying the pathology of osteoporosis, supporting a model of age-related dysregulation and crosstalk in the bone microenvironment.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2016.06.002