Genetic variation associated with preterm birth in African-American women

Background Preterm birth is considered a multifactorial condition; however, emerging evidence suggests that genetic variation among individuals may have an important role. Prior studies have suggested that single-nucleotide polymorphisms associated with genes related to the immune system, and partic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of obstetrics and gynecology 2016-08, Vol.215 (2), p.235.e1-235.e8
Hauptverfasser:	Frey, Heather A., MD, MSCI, Stout, Molly J., MD, MSCI, Pearson, Laurel N., PhD, Tuuli, Methodius G., MD, MPH, Cahill, Alison G., MD, MSCI, Strauss, Jerome F., MD, PhD, Gomez, Luis M., MD, Parry, Samuel, MD, Allsworth, Jenifer E., PhD, Macones, George A., MD, MSCE
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans - genetics Alleles Female Genetic Predisposition to Disease genetics Genotype Humans inflammation Interleukin-16 - genetics Matrix Metalloproteinase 2 - genetics Obstetric Labor, Premature - genetics Obstetrics and Gynecology Polymorphism, Single Nucleotide Pregnancy Premature Birth - genetics preterm birth Protein Kinase C-alpha - genetics Tissue Inhibitor of Metalloproteinase-2 - genetics Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background Preterm birth is considered a multifactorial condition; however, emerging evidence suggests that genetic variation among individuals may have an important role. Prior studies have suggested that single-nucleotide polymorphisms associated with genes related to the immune system, and particularly the maternal inflammatory response, may be associated with an increased risk of preterm delivery. Objective The objective of the study was to identify single-nucleotide polymorphisms associated with spontaneous preterm birth
ISSN:	0002-9378 1097-6868
DOI:	10.1016/j.ajog.2016.03.008