Rapid genotype imputation from sequence without reference panels

Richard Mott, Simon Myers and colleagues present a new imputation method, STITCH, which does not require genotyping arrays or high-quality reference panels. They use STITCH to accurately impute genotypes in both outbred laboratory mice and a sample human population directly from low-coverage (

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2016-08, Vol.48 (8), p.965-969
Hauptverfasser:	Davies, Robert W, Flint, Jonathan, Myers, Simon, Mott, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2785 631/208/514 Accuracy Agriculture Algorithms Animal Genetics and Genomics Animals Animals, Outbred Strains - genetics Arrays Asian People - genetics Biomedicine Cancer Research Chromosomes Computational Biology - methods Gene Function Genetics, Population Genome-wide association studies Genomes Genotype Genotype & phenotype Genotypes Haplotypes Haplotypes - genetics High-Throughput Nucleotide Sequencing Human Genetics Humans Identification and classification Methods Mice Polymorphism, Single Nucleotide - genetics Quality Sequence Analysis, DNA - methods Single nucleotide polymorphisms technical-report
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Beschreibung
Zusammenfassung:	Richard Mott, Simon Myers and colleagues present a new imputation method, STITCH, which does not require genotyping arrays or high-quality reference panels. They use STITCH to accurately impute genotypes in both outbred laboratory mice and a sample human population directly from low-coverage (
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.3594