Modulatory effect of Mangifera indica against carbon tetrachloride induced kidney damage in rats

There is little scientific evidence on the local use of in kidney diseases. This study investigated the reno-modulatory roles of the aqueous stem bark extract of (MIASE) against CCl -induced renal damage. Rats were treated intragastrically with 125, 250 and 500 mg/kg/day MIASE for 7 days before and after the administration of CCl (3 ml/kg of 30% CCl , i.p.). Serum levels of electrolytes (Na , K , Cl , HCO ), urea and creatinine were determined. Renal tissue reduced glutathione (GSH), malondialdehyde (MDA), catalase (CAT), superoxide (SOD) activities were also assessed. The histopathological changes in kidneys were determined using standard methods. In CCl treated rats the results showed significant (