Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents

Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents

A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of chemical biology 2016-07, Vol.9 (3), p.79-90
Hauptverfasser: Sindhe, M. Aruna, Bodke, Yadav D., Kenchappa, R., Telkar, Sandeep, Chandrashekar, A.
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
Antioxidants
Biochemistry
Biological and Medical Physics
Biophysics
Cell Biology
Chemical synthesis
Chemistry
Chemistry and Materials Science
Derivatives
Molecular chains
Molecular docking
Molecular structure
Original
Original Article
Oxadiazoles
Pharmacology/Toxicology
Physical Chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.
ISSN:1864-6158
1864-6166
DOI:10.1007/s12154-016-0153-9