Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders
Highlights • There is a reduction in dendritic spines in young and adult MIA offspring. • Dendritic spines in MIA offspring are less dynamic. • In MIA offspring there is altered structural and functional excitatory and inhibitory synaptic connectivity. • Postnatal anti-inflammatory treatment prevent...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.249-258 |
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| creator | Coiro, Pierluca Padmashri, Ragunathan Suresh, Anand Spartz, Elizabeth Pendyala, Gurudutt Chou, Shinnyi Jung, Yoosun Meays, Brittney Roy, Shreya Gautam, Nagsen Alnouti, Yazen Li, Ming Dunaevsky, Anna |
| description | Highlights • There is a reduction in dendritic spines in young and adult MIA offspring. • Dendritic spines in MIA offspring are less dynamic. • In MIA offspring there is altered structural and functional excitatory and inhibitory synaptic connectivity. • Postnatal anti-inflammatory treatment prevents both behavioral and synaptic impairments. |
| doi_str_mv | 10.1016/j.bbi.2015.07.022 |
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pharmacology</subject><subject>Autism</subject><subject>Dendritic spines</subject><subject>Dendritic Spines - drug effects</subject><subject>Dendritic Spines - immunology</subject><subject>Disease Models, Animal</subject><subject>Excitation</subject><subject>Excitatory Postsynaptic Potentials</subject><subject>Female</subject><subject>Inflammation</subject><subject>Inhibition</subject><subject>Maternal-Fetal Exchange</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurodevelopmental Disorders - etiology</subject><subject>Neurodevelopmental Disorders - immunology</subject><subject>Neurons - drug effects</subject><subject>Neurons - immunology</subject><subject>Pregnancy</subject><subject>Psychiatry</subject><subject>Pyridines - pharmacology</subject><subject>Somatosensory Cortex - drug effects</subject><subject>Somatosensory Cortex - growth & development</subject><subject>Somatosensory Cortex - immunology</subject><subject>Synapses - drug effects</subject><subject>Synapses - 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| ispartof | Brain, behavior, and immunity, 2015-11, Vol.50, p.249-258 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animals Anti-inflammatory Anti-Inflammatory Agents - pharmacology Autism Dendritic spines Dendritic Spines - drug effects Dendritic Spines - immunology Disease Models, Animal Excitation Excitatory Postsynaptic Potentials Female Inflammation Inhibition Maternal-Fetal Exchange Mice Mice, Inbred C57BL Neurodevelopmental Disorders - etiology Neurodevelopmental Disorders - immunology Neurons - drug effects Neurons - immunology Pregnancy Psychiatry Pyridines - pharmacology Somatosensory Cortex - drug effects Somatosensory Cortex - growth & development Somatosensory Cortex - immunology Synapses - drug effects Synapses - immunology |
| title | Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders |
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