Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

Highlights • There is a reduction in dendritic spines in young and adult MIA offspring. • Dendritic spines in MIA offspring are less dynamic. • In MIA offspring there is altered structural and functional excitatory and inhibitory synaptic connectivity. • Postnatal anti-inflammatory treatment prevent...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.249-258
Hauptverfasser:	Coiro, Pierluca, Padmashri, Ragunathan, Suresh, Anand, Spartz, Elizabeth, Pendyala, Gurudutt, Chou, Shinnyi, Jung, Yoosun, Meays, Brittney, Roy, Shreya, Gautam, Nagsen, Alnouti, Yazen, Li, Ming, Dunaevsky, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anti-inflammatory Anti-Inflammatory Agents - pharmacology Autism Dendritic spines Dendritic Spines - drug effects Dendritic Spines - immunology Disease Models, Animal Excitation Excitatory Postsynaptic Potentials Female Inflammation Inhibition Maternal-Fetal Exchange Mice Mice, Inbred C57BL Neurodevelopmental Disorders - etiology Neurodevelopmental Disorders - immunology Neurons - drug effects Neurons - immunology Pregnancy Psychiatry Pyridines - pharmacology Somatosensory Cortex - drug effects Somatosensory Cortex - growth & development Somatosensory Cortex - immunology Synapses - drug effects Synapses - immunology
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Zusammenfassung:	Highlights • There is a reduction in dendritic spines in young and adult MIA offspring. • Dendritic spines in MIA offspring are less dynamic. • In MIA offspring there is altered structural and functional excitatory and inhibitory synaptic connectivity. • Postnatal anti-inflammatory treatment prevents both behavioral and synaptic impairments.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.07.022