Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents

Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents

Series of styryl hydrazine thiazole hybrids inspired from dehydrozingerone (DZG) scaffold were designed and synthesized by molecular hybridization approach. In vitro antimycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, c...

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Veröffentlicht in:ACS medicinal chemistry letters 2016-07, Vol.7 (7), p.686-691
Hauptverfasser: Hampannavar, Girish A, Karpoormath, Rajshekhar, Palkar, Mahesh B, Shaikh, Mahamadhanif S, Chandrasekaran, Balakumar
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Sprache:eng
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Zusammenfassung:Series of styryl hydrazine thiazole hybrids inspired from dehydrozingerone (DZG) scaffold were designed and synthesized by molecular hybridization approach. In vitro antimycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, compound 6o exhibited significant activity (MIC = 1.5 μM; IC50 = 0.48 μM) along with bactericidal (MBC = 12 μM) and intracellular antimycobacterial activities (IC50 =
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.6b00088