Targeted radiotherapy enhancement during electronic brachytherapy of accelerated partial breast irradiation (APBI) using controlled release of gold nanoparticles

Highlights • We propose to use gold nanoparticles (GNPs) during APBI to provide dose boost. • We propose delivery of GNPs by coating the Xoft balloon applicator. • We calculate the dose enhancement factor by performing analytical calculations. • Dose enhancement values of 1.2 were found 6 mm away fr...

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Veröffentlicht in:	Physica medica 2015-12, Vol.31 (8), p.1070-1074
Hauptverfasser:	Cifter, G, Chin, J, Cifter, F, Altundal, Y, Sinha, N, Sajo, E, Ngwa, W
Format:	Artikel
Sprache:	eng
Schlagworte:	50 kVp APBI Brachytherapy - instrumentation Breast - drug effects Breast - radiation effects Breast Neoplasms - radiotherapy Delayed-Action Preparations Dose enhancement Electrical Equipment and Supplies Feasibility Studies Gold Gold - administration & dosage Gold - chemistry Gold - pharmacology Humans Metal Nanoparticles Nanoparticles Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacology Radiology Radiometry Radiotherapy Dosage Xoft electronic brachytherapy
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Beschreibung
Zusammenfassung:	Highlights • We propose to use gold nanoparticles (GNPs) during APBI to provide dose boost. • We propose delivery of GNPs by coating the Xoft balloon applicator. • We calculate the dose enhancement factor by performing analytical calculations. • Dose enhancement values of 1.2 were found 6 mm away from lumpectomy cavity surface.
ISSN:	1120-1797 1724-191X
DOI:	10.1016/j.ejmp.2015.07.138