Development of a translational model to screen medications for cocaine use disorder I: Choice between cocaine and food in rhesus monkeys

Highlights • Homologous procedures were established for cocaine choice in monkeys and humans. • Choice was governed by cocaine dose and magnitude of the alternative non-drug reinforcer. • Cocaine choice dose-effect curves in monkeys and humans were highly correlated. • Lisdexamfetamine treatment sel...

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Veröffentlicht in:	Drug and alcohol dependence 2016-08, Vol.165, p.103-110
Hauptverfasser:	Johnson, Amy R, Banks, Matthew L, Blough, Bruce E, Lile, Joshua A, Nicholson, Katherine L, Negus, S. Stevens
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Choice Choice Behavior - drug effects Cocaine Cocaine - antagonists & inhibitors Cocaine - pharmacology Dose-Response Relationship, Drug Food Human Lisdexamfetamine Lisdexamfetamine Dimesylate - pharmacology Macaca mulatta Male Psychiatry Reinforcement Schedule Rhesus monkey Self Administration Translation Translational Medical Research - methods
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Zusammenfassung:	Highlights • Homologous procedures were established for cocaine choice in monkeys and humans. • Choice was governed by cocaine dose and magnitude of the alternative non-drug reinforcer. • Cocaine choice dose-effect curves in monkeys and humans were highly correlated. • Lisdexamfetamine treatment selectively decreased cocaine choice in monkeys. • This platform will be useful for translational testing of candidate medications.
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2016.05.021