Factors associated with late recurrence after completion of 5-year adjuvant tamoxifen in estrogen receptor positive breast cancer

Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. We reviewed our database of ER-positiv...

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Veröffentlicht in:BMC cancer 2016-07, Vol.16 (1), p.430-430, Article 430
Hauptverfasser: Lee, Eun-Shin, Han, Wonshik, Kim, Min Kyoon, Kim, Jongjin, Yoo, Tae-Kyung, Lee, Moo Hyun, Lee, Kyung Hun, Kim, Tae Yong, Moon, Hyeong-Gon, Im, Seock-Ah, Noh, Dong-Young, Lee, Eun Sook
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Sprache:eng
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Zusammenfassung:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. We reviewed our database of ER-positive patients who had received operations between 1996 and 2006 in two institutions. We selected 444 who had completed 5-year tamoxifen and were disease-free up to 10 years after the operation. Patients who had received aromatase inhibitors with any regimens were excluded. As a late recurrence group, 139 patients were identified who had completed 5-year tamoxifen, but had recurrence afterwards. Among them, 61 had local/contralateral breast recurrence and 78 had distant metastasis. The median follow-up was 9.7 years. Clinicopathological factors at the time of initial operation, such as age, menopausal status, progesterone receptor expression, HER2 status, tumor grade and Ki-67, were compared between the disease-free group and the late recurrence group. In a univariate analysis, tumor size (>2 cm), lymph node metastasis and high histologic grade were significantly associated with late recurrences (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-016-2423-x