Comparable reduction in Zif268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions

Highlights • Mammillothalamic tract lesions impaired T-maze alternation performance. • Mammillothalamic tract lesions reduced Zif268 levels in retrosplenial cortex. • Mammillothalamic tract lesions reduced cytochrome oxidase in retrosplenial cortex. • No changes were found in the dorsal hippocampus....

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Veröffentlicht in:	Neuroscience 2016-08, Vol.330, p.39-49
Hauptverfasser:	Frizzati, Aura, Milczarek, Michal M, Sengpiel, Frank, Thomas, Kerrie L, Dillingham, Christopher M, Vann, Seralynne D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals anterior thalamic nuclei Cell Count Cerebral Cortex - metabolism Cerebral Cortex - pathology Cohort Studies diencephalic amnesia Disease Models, Animal Early Growth Response Protein 1 - metabolism Electric Stimulation Electron Transport Complex IV - metabolism hippocampus Hippocampus - metabolism Hippocampus - pathology immediate-early gene Immunohistochemistry mammillary bodies Mammillary Bodies - injuries Mammillary Bodies - metabolism Mammillary Bodies - pathology Maze Learning - physiology memory Memory Disorders - etiology Memory Disorders - metabolism Memory Disorders - pathology Neural Pathways - injuries Neural Pathways - metabolism Neural Pathways - pathology Neurology Rats Thalamus - injuries Thalamus - metabolism Thalamus - pathology
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Zusammenfassung:	Highlights • Mammillothalamic tract lesions impaired T-maze alternation performance. • Mammillothalamic tract lesions reduced Zif268 levels in retrosplenial cortex. • Mammillothalamic tract lesions reduced cytochrome oxidase in retrosplenial cortex. • No changes were found in the dorsal hippocampus. • These distal changes may contribute to the memory impairments.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.05.030