Poor growth, thyroid dysfunction and vitamin D deficiency remain prevalent despite reduced intensity chemotherapy for hematopoietic stem cell transplantation in children and young adults

Myeloablative conditioning regimens for hematopoietic stem cell transplant (HSCT) are known to affect endocrine function, but little is known regarding reduced intensity conditioning (RIC) regimens. We retrospectively reviewed 114 children and young adults after single RIC HSCT. The analysis was gro...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2016-07, Vol.51 (7), p.980-984
Hauptverfasser:	Myers, K C, Howell, J C, Wallace, G, Dandoy, C, El-Bietar, J, Lane, A, Davies, S M, Jodele, S, Rose, S R
Format:	Artikel
Sprache:	eng
Schlagworte:	692/499 692/700/1720 692/700/784 Adolescent Adults Age Factors Body mass Body Mass Index Body size Bone Density Bone marrow Bone mineral density Calciferol Cell Biology Chemotherapy Child Children Complications and side effects Conditioning Disorders Endocrine diseases Genetic disorders Graft-versus-host reaction Growth Disorders - etiology Heat affected zone Hematology Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Internal Medicine Lymphocytes Medicine Medicine & Public Health Metabolism Methods Myeloablative Agonists - administration & dosage Myeloablative Agonists - pharmacology original-article Patient outcomes Prophylaxis Public Health Retrospective Studies Risk factors Stem cell transplantation Stem Cells Thyroid Thyroid diseases Thyroid Diseases - etiology Thyroid gland Transplantation Transplantation Conditioning - adverse effects Transplantation Conditioning - methods Transplants & implants Vitamin D Vitamin D Deficiency - etiology Vitamin deficiency Young Adult Young adults
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Zusammenfassung:	Myeloablative conditioning regimens for hematopoietic stem cell transplant (HSCT) are known to affect endocrine function, but little is known regarding reduced intensity conditioning (RIC) regimens. We retrospectively reviewed 114 children and young adults after single RIC HSCT. The analysis was grouped by age (
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2016.39