Parkinson’s disease and enhanced inflammatory response

Parkinson’s disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a loss of midbrain dopaminergic (DA) neurons. However, the molecular cause of DA neuron loss remains elusive. Mounting evidence implicates enhanc...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2015-11, Vol.240 (11), p.1387-1395
Hauptverfasser:	Stojkovska, Iva, Wagner, Brandon M, Morrison, Brad E
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - chemistry Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Cytokines - metabolism Disease Models, Animal Dopamine - metabolism Dopaminergic Neurons - metabolism Humans Inflammation - pathology Lipopolysaccharides - chemistry Minireviews Neurons - metabolism Oxidative Stress Oxidopamine - chemistry Oxygen - chemistry Paraquat - chemistry Parkinson Disease - immunology Parkinson Disease - physiopathology Ubiquitin-Protein Ligases - metabolism
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Beschreibung
Zusammenfassung:	Parkinson’s disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a loss of midbrain dopaminergic (DA) neurons. However, the molecular cause of DA neuron loss remains elusive. Mounting evidence implicates enhanced inflammatory response in the development and progression of PD pathology. This review examines current research connecting PD and inflammatory response.
ISSN:	1535-3702 1535-3699
DOI:	10.1177/1535370215576313