Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers
Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This stu...
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| Veröffentlicht in: | British journal of cancer 2016-06, Vol.115 (1), p.25-33 |
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| creator | Kim, Chang Gon Ahn, Joong Bae Jung, Minkyu Beom, Seung Hoon Kim, Chan Kim, Joo Hoon Heo, Su Jin Park, Hyung Soon Kim, Jee Hung Kim, Nam Kyu Min, Byung Soh Kim, Hoguen Koom, Woong Sub Shin, Sang Joon |
| description | Background:
Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs.
Methods:
This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed.
Results:
A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619,
P |
| doi_str_mv | 10.1038/bjc.2016.161 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4931375</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808657679</sourcerecordid><originalsourceid>FETCH-LOGICAL-c549t-36479263c8fd9ae66b144510e86ed872e8990bf5d39c6032e14c0bd4c091a94b3</originalsourceid><addsrcrecordid>eNqNkcuLFDEQh4Mo7uzozbMEvHjYHlNJdx4XQZb1AQte9BzS6eq1h-5kTNLC_vdmnHVZxYOXPKiPXyX1EfIC2A6Y0G_6vd9xBnIHEh6RDXSCN6C5ekw2jDHVMMPZGTnPeV-vhmn1lJxxxbnmWm2IvRpH9CXTONJl8ilmV3Cep4J0Crm4fqrnWxoDTejXlDB4pAdXCqaQqQsDjWvxccFceerjHCtX3Ey9q2TKz8iT0c0Zn9_tW_L1_dWXy4_N9ecPny7fXTe-a01phGyV4VJ4PQ7GoZQ9tG0HDLXEQSuO2hjWj90gjJdMcITWs36oiwFn2l5sydtT7mHtFxw8hpLcbA9pWly6tdFN9s9KmL7Zm_jDtkaAUF0NeH0XkOL3FXOxy5R9HYULGNdsQTMtOyWV-R-UKQZGtxV99Re6j2sKdRK_KBAaqsQtuThRx_nnhOP9u4HZo2RbJdujZFslV_zlw7_ew7-tVqA5AbmWwg2mB13_FfgTYtKyRA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1800138110</pqid></control><display><type>article</type><title>Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>PubMed Central</source><creator>Kim, Chang Gon ; Ahn, Joong Bae ; Jung, Minkyu ; Beom, Seung Hoon ; Kim, Chan ; Kim, Joo Hoon ; Heo, Su Jin ; Park, Hyung Soon ; Kim, Jee Hung ; Kim, Nam Kyu ; Min, Byung Soh ; Kim, Hoguen ; Koom, Woong Sub ; Shin, Sang Joon</creator><creatorcontrib>Kim, Chang Gon ; Ahn, Joong Bae ; Jung, Minkyu ; Beom, Seung Hoon ; Kim, Chan ; Kim, Joo Hoon ; Heo, Su Jin ; Park, Hyung Soon ; Kim, Jee Hung ; Kim, Nam Kyu ; Min, Byung Soh ; Kim, Hoguen ; Koom, Woong Sub ; Shin, Sang Joon</creatorcontrib><description>Background:
Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs.
Methods:
This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed.
Results:
A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619,
P
<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0%
vs
12.0%,
P
=0.032) or peritoneal metastasis (40.0%
vs
12.3%,
P
=0.003), and less frequent lung (10.0%
vs
42.5%,
P
=0.004) or liver metastases (15.0%
vs
44.7%,
P
=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363,
P
=0.035) and OS2 (HR: 2.667,
P
<0.001). An analysis of patients with colon cancer yielded similar results.
Conclusions:
Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2016.161</identifier><identifier>PMID: 27228287</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/211/2120 ; 692/4028/67/1504/1885 ; 692/700/1750 ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chemotherapy ; Clinical Study ; Colonoscopy ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Disease-Free Survival ; Drug Resistance ; Epidemiology ; Female ; Humans ; Internal medicine ; Lymphatic system ; Male ; Medical prognosis ; Microsatellite Instability ; Microsatellite Repeats - genetics ; Middle Aged ; Molecular Medicine ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Oncology ; Patients ; Prognosis ; Proportional Hazards Models ; Surgery ; Tomography ; Tumors ; Yeast ; Young Adult</subject><ispartof>British journal of cancer, 2016-06, Vol.115 (1), p.25-33</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 28, 2016</rights><rights>Copyright © 2016 Cancer Research UK 2016 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-36479263c8fd9ae66b144510e86ed872e8990bf5d39c6032e14c0bd4c091a94b3</citedby><cites>FETCH-LOGICAL-c549t-36479263c8fd9ae66b144510e86ed872e8990bf5d39c6032e14c0bd4c091a94b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931375/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931375/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27228287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Chang Gon</creatorcontrib><creatorcontrib>Ahn, Joong Bae</creatorcontrib><creatorcontrib>Jung, Minkyu</creatorcontrib><creatorcontrib>Beom, Seung Hoon</creatorcontrib><creatorcontrib>Kim, Chan</creatorcontrib><creatorcontrib>Kim, Joo Hoon</creatorcontrib><creatorcontrib>Heo, Su Jin</creatorcontrib><creatorcontrib>Park, Hyung Soon</creatorcontrib><creatorcontrib>Kim, Jee Hung</creatorcontrib><creatorcontrib>Kim, Nam Kyu</creatorcontrib><creatorcontrib>Min, Byung Soh</creatorcontrib><creatorcontrib>Kim, Hoguen</creatorcontrib><creatorcontrib>Koom, Woong Sub</creatorcontrib><creatorcontrib>Shin, Sang Joon</creatorcontrib><title>Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs.
Methods:
This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed.
Results:
A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619,
P
<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0%
vs
12.0%,
P
=0.032) or peritoneal metastasis (40.0%
vs
12.3%,
P
=0.003), and less frequent lung (10.0%
vs
42.5%,
P
=0.004) or liver metastases (15.0%
vs
44.7%,
P
=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363,
P
=0.035) and OS2 (HR: 2.667,
P
<0.001). An analysis of patients with colon cancer yielded similar results.
Conclusions:
Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.</description><subject>631/208/211/2120</subject><subject>692/4028/67/1504/1885</subject><subject>692/700/1750</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Clinical Study</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease-Free Survival</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Microsatellite Instability</subject><subject>Microsatellite Repeats - genetics</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Yeast</subject><subject>Young Adult</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkcuLFDEQh4Mo7uzozbMEvHjYHlNJdx4XQZb1AQte9BzS6eq1h-5kTNLC_vdmnHVZxYOXPKiPXyX1EfIC2A6Y0G_6vd9xBnIHEh6RDXSCN6C5ekw2jDHVMMPZGTnPeV-vhmn1lJxxxbnmWm2IvRpH9CXTONJl8ilmV3Cep4J0Crm4fqrnWxoDTejXlDB4pAdXCqaQqQsDjWvxccFceerjHCtX3Ey9q2TKz8iT0c0Zn9_tW_L1_dWXy4_N9ecPny7fXTe-a01phGyV4VJ4PQ7GoZQ9tG0HDLXEQSuO2hjWj90gjJdMcITWs36oiwFn2l5sydtT7mHtFxw8hpLcbA9pWly6tdFN9s9KmL7Zm_jDtkaAUF0NeH0XkOL3FXOxy5R9HYULGNdsQTMtOyWV-R-UKQZGtxV99Re6j2sKdRK_KBAaqsQtuThRx_nnhOP9u4HZo2RbJdujZFslV_zlw7_ew7-tVqA5AbmWwg2mB13_FfgTYtKyRA</recordid><startdate>20160628</startdate><enddate>20160628</enddate><creator>Kim, Chang Gon</creator><creator>Ahn, Joong Bae</creator><creator>Jung, Minkyu</creator><creator>Beom, Seung Hoon</creator><creator>Kim, Chan</creator><creator>Kim, Joo Hoon</creator><creator>Heo, Su Jin</creator><creator>Park, Hyung Soon</creator><creator>Kim, Jee Hung</creator><creator>Kim, Nam Kyu</creator><creator>Min, Byung Soh</creator><creator>Kim, Hoguen</creator><creator>Koom, Woong Sub</creator><creator>Shin, Sang Joon</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160628</creationdate><title>Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers</title><author>Kim, Chang Gon ; Ahn, Joong Bae ; Jung, Minkyu ; Beom, Seung Hoon ; Kim, Chan ; Kim, Joo Hoon ; Heo, Su Jin ; Park, Hyung Soon ; Kim, Jee Hung ; Kim, Nam Kyu ; Min, Byung Soh ; Kim, Hoguen ; Koom, Woong Sub ; Shin, Sang Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-36479263c8fd9ae66b144510e86ed872e8990bf5d39c6032e14c0bd4c091a94b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/208/211/2120</topic><topic>692/4028/67/1504/1885</topic><topic>692/700/1750</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Clinical Study</topic><topic>Colonoscopy</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Disease-Free Survival</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Microsatellite Instability</topic><topic>Microsatellite Repeats - genetics</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Yeast</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Chang Gon</creatorcontrib><creatorcontrib>Ahn, Joong Bae</creatorcontrib><creatorcontrib>Jung, Minkyu</creatorcontrib><creatorcontrib>Beom, Seung Hoon</creatorcontrib><creatorcontrib>Kim, Chan</creatorcontrib><creatorcontrib>Kim, Joo Hoon</creatorcontrib><creatorcontrib>Heo, Su Jin</creatorcontrib><creatorcontrib>Park, Hyung Soon</creatorcontrib><creatorcontrib>Kim, Jee Hung</creatorcontrib><creatorcontrib>Kim, Nam Kyu</creatorcontrib><creatorcontrib>Min, Byung Soh</creatorcontrib><creatorcontrib>Kim, Hoguen</creatorcontrib><creatorcontrib>Koom, Woong Sub</creatorcontrib><creatorcontrib>Shin, Sang Joon</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Chang Gon</au><au>Ahn, Joong Bae</au><au>Jung, Minkyu</au><au>Beom, Seung Hoon</au><au>Kim, Chan</au><au>Kim, Joo Hoon</au><au>Heo, Su Jin</au><au>Park, Hyung Soon</au><au>Kim, Jee Hung</au><au>Kim, Nam Kyu</au><au>Min, Byung Soh</au><au>Kim, Hoguen</au><au>Koom, Woong Sub</au><au>Shin, Sang Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2016-06-28</date><risdate>2016</risdate><volume>115</volume><issue>1</issue><spage>25</spage><epage>33</epage><pages>25-33</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs.
Methods:
This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed.
Results:
A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619,
P
<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0%
vs
12.0%,
P
=0.032) or peritoneal metastasis (40.0%
vs
12.3%,
P
=0.003), and less frequent lung (10.0%
vs
42.5%,
P
=0.004) or liver metastases (15.0%
vs
44.7%,
P
=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363,
P
=0.035) and OS2 (HR: 2.667,
P
<0.001). An analysis of patients with colon cancer yielded similar results.
Conclusions:
Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27228287</pmid><doi>10.1038/bjc.2016.161</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online; PubMed Central |
| subjects | 631/208/211/2120 692/4028/67/1504/1885 692/700/1750 Adolescent Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Chemotherapy Clinical Study Colonoscopy Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease-Free Survival Drug Resistance Epidemiology Female Humans Internal medicine Lymphatic system Male Medical prognosis Microsatellite Instability Microsatellite Repeats - genetics Middle Aged Molecular Medicine Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Oncology Patients Prognosis Proportional Hazards Models Surgery Tomography Tumors Yeast Young Adult |
| title | Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
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