Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers

Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This stu...

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Veröffentlicht in:British journal of cancer 2016-06, Vol.115 (1), p.25-33
Hauptverfasser: Kim, Chang Gon, Ahn, Joong Bae, Jung, Minkyu, Beom, Seung Hoon, Kim, Chan, Kim, Joo Hoon, Heo, Su Jin, Park, Hyung Soon, Kim, Jee Hung, Kim, Nam Kyu, Min, Byung Soh, Kim, Hoguen, Koom, Woong Sub, Shin, Sang Joon
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Sprache:eng
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Zusammenfassung:Background: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. Methods: This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. Results: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2016.161