Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice

Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) has been implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling. We investigated the functional consequences of partial and full Sgta ablation in vivo using Cre-lox Sgta -null m...

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Veröffentlicht in:Scientific reports 2016-06, Vol.6 (1), p.28950-28950, Article 28950
Hauptverfasser: Philp, Lisa K., Day, Tanya K., Butler, Miriam S., Laven-Law, Geraldine, Jindal, Shalini, Hickey, Theresa E., Scher, Howard I., Butler, Lisa M., Tilley, Wayne D.
Format: Artikel
Sprache:eng
Schlagworte:
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Ablation
Animals
Body Size
Cancer research
Cell cycle
Female
Females
Health sciences
Histology
Humanities and Social Sciences
Male
Males
Medical research
Mice
Mice, Knockout
Molecular Chaperones - genetics
Molecular Chaperones - metabolism
multidisciplinary
Offspring
Ovaries
Prostate
Proteins
Science
Survival Analysis
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Zusammenfassung:Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) has been implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling. We investigated the functional consequences of partial and full Sgta ablation in vivo using Cre-lox Sgta -null mice. Sgta +/− breeders generated viable Sgta −/− offspring, but at less than Mendelian expectancy. S gta −/− breeders were subfertile with small litters and higher neonatal death ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep28950