Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

Altered metabolism is a hallmark of cancer. However, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be elucidated. Here, we have investigated the genomic and transcriptomic changes underlying this shift across ten different cancer types. A systematic pan...

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Veröffentlicht in:	Genome Biology 2016-06, Vol.17 (1), p.140-140, Article 140
Hauptverfasser:	Haider, Syed, McIntyre, Alan, van Stiphout, Ruud G P M, Winchester, Laura M, Wigfield, Simon, Harris, Adrian L, Buffa, Francesca M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor biosynthesis Breast cancer breasts Cancer Cancer therapies Cell Line, Tumor Cell survival Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism cell viability Cholesterol Chromosomes Cluster Analysis Colorectal carcinoma colorectal neoplasms Complications and side effects Copy number data collection Deoxyribonucleic acid Disease Models, Animal DNA DNA Copy Number Variations Energy Metabolism - genetics Enzymes Female Gene expression Gene Expression Profiling Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene frequency Genes Genetic aspects Genetic Association Studies Genetic Variation Genomes Genomic Instability Genomics Genomics - methods Heterografts Humans Hypotheses Hypoxia Kidney cancer kidney neoplasms messenger RNA Metabolism Mice Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - mortality Neoplasms - pathology Pancreatic cancer Prognosis Signal transduction Squalene Squalene epoxidase Transcriptome transcriptomics Tumor cell lines Tumor Hypoxia - genetics Tumors
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Zusammenfassung:	Altered metabolism is a hallmark of cancer. However, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be elucidated. Here, we have investigated the genomic and transcriptomic changes underlying this shift across ten different cancer types. A systematic pan-cancer analysis of 6538 tumour/normal samples covering ten major cancer types identified a core metabolic signature of 44 genes that exhibit high frequency somatic copy number gains/amplifications (>20 % cases) associated with increased mRNA expression (ρ > 0.3, q
ISSN:	1474-760X 1474-7596 1474-760X
DOI:	10.1186/s13059-016-0999-8