Glioblastoma Multiforme in a Post Allogeneic Stem Cell Transplant Patient. A Case Report and Literature Review of Post Transplant Neurological Tumors

Seventeen year old boy, a case of relapsed acute lymphoblastic leukemia 10 years post allogeneic transplantation, presented to us with acute onset of right hemiparesis. The imaging revealed contrast enhancing lesion in the frontal lobe, biopsy of the same was consistent with glioblastoma multiforme (GBM). He had received total body irradiation (TBI) based conditioning regimen prior to transplant. GBM was treated with left parietal craniotomy and parietal excision of tumour, followed by radiation therapy with concurrent and adjuvant chemotherapy. Disease progressed while was on adjuvant chemotherapy and patient succumbed to his illness 8 months after the diagnosis of GBM. We report here a here unusual case of GBM in a post transplant patient who received TBI based conditioning regimen.