Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state

Highlights • TAK-242 prevents LPS evoked TNF release from RAW267.4 cells and male and female macrophages. • IV, IT, and IP TAK-242 administration prevents LPS-induced allodynia in males. • TLR4 deficiency and TAK-242 treatment prevents the delayed onset of formalin-induced tactile allodynia in both sexes. • TAK-242 does not reverse established tactile allodynia in the current experiments.