Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia

Highlights • MBP84-104 peptide, injected into an intact nerve, produces long-lasting pain. • IL-6 is the top-induced cytokine by MBP84-104, regardless of T cell content. • Blockade of spinal IL-6 activity reduces MBP84-104-induced pain. • Gabapentin, but not ketorolac, lidocaine or MK801 reverses MB...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.378-389
Hauptverfasser:	Ko, Justin S, Eddinger, Kelly A, Angert, Mila, Chernov, Andrei V, Dolkas, Jennifer, Strongin, Alex Y, Yaksh, Tony L, Shubayev, Veronica I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Allergy and Immunology Allodynia Amines - pharmacology Animals Autoimmunity and pain Cacna2d1 Calcium Channel Blockers - pharmacology Chronic pain Cyclohexanecarboxylic Acids - pharmacology Cyclooxygenase Inhibitors - pharmacology Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Female Female pain Gabapentin gamma-Aminobutyric Acid - pharmacology Genomics Hyperalgesia - chemically induced Hyperalgesia - drug therapy Interferon Interleukin 6 Interleukin-6 - immunology Interleukin-6 - metabolism Ketorolac - pharmacology Lidocaine - pharmacology MBP Mechanical hypersensitivity Myelin Myelin basic protein Myelin Basic Protein - administration & dosage Myelin Basic Protein - pharmacology Neuropathic pain Nude rat Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Psychiatry Rats Rats, Nude Rats, Sprague-Dawley Sciatic Nerve - drug effects Spinal Cord - metabolism T cells Voltage-Gated Sodium Channel Blockers - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • MBP84-104 peptide, injected into an intact nerve, produces long-lasting pain. • IL-6 is the top-induced cytokine by MBP84-104, regardless of T cell content. • Blockade of spinal IL-6 activity reduces MBP84-104-induced pain. • Gabapentin, but not ketorolac, lidocaine or MK801 reverses MBP84-104-induced pain.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.03.003