Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus

Highlights • Hippocampal excitatory and inhibitory neurons in mice express CB2R mRNAs. • Only a subset of hippocampal neurons express CB2 cannabinoid receptor mRNAs. • Levels of hippocampal CB2R mRNAs are stable during postnatal development. • The expression of CB2 cannabinoid receptor mRNAs is augm...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.311, p.253-267
Hauptverfasser:	Li, Y, Kim, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western cannabinoid CB2 cannabinoid receptor confocal microscopy Glutamic Acid - metabolism Hippocampus - growth & development Hippocampus - metabolism Immunohistochemistry in situ hybridization In Situ Hybridization - methods Mice, Inbred C57BL Mice, Knockout Microglia - metabolism Microscopy, Confocal Neurology Neurons - metabolism Polymerase Chain Reaction Receptor, Cannabinoid, CB2 - genetics Receptor, Cannabinoid, CB2 - metabolism RNA, Messenger - metabolism RNAscope Tissue Culture Techniques
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Zusammenfassung:	Highlights • Hippocampal excitatory and inhibitory neurons in mice express CB2R mRNAs. • Only a subset of hippocampal neurons express CB2 cannabinoid receptor mRNAs. • Levels of hippocampal CB2R mRNAs are stable during postnatal development. • The expression of CB2 cannabinoid receptor mRNAs is augmented in cultured tissue.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.041